What Oil is the Best Carrier Oil for CBD?

CBD Oil is a tincture which is one of the most common and best methods to take CBD. A tincture uses a carrier oil which is then mixed with the CBD oil. This creates a product that is easy to use. It is taken under the tongue, sublingual, so it absorbs quickly into the blood steam via the mucus membrane and blood vessels under the tongue.

CBD is infused into oil-based solutions, where it binds with fat molecules your body is already prone to breaking down. Once the CBD is evenly distributed throughout the oil, it is possible to evenly measure consistent amounts of CBD that your body can process. This way you count the drops that is taken, finding the right dosage for you. 

If the CBD oil was not mixed with a carrier oil, it would be a thick sticky pasty substance that would stick to your teeth and be harder for most people to consume. Not to mention the taste is unbearable for many people.

Bioavailability, or how readily the body can absorb the oil, is the biggest concern when determining the best carrier oil. CBD’s bioavailability is largely determined by the types of fat molecules contained in the carrier oil. There are many different types of fat and the way they vary on a molecular level affects how well it can transport CBD into your system. Besides bioavailability, individual differences between oils such as flavor, consistency, and cost may affect their viability as carrier oils. 

 

Hemp Seed Oil

It’s worth pointing out that the hemp plant actually produces a super high-quality essential oil from its seeds, that, in addition to being filled with therapeutic CBD, is chock-full of other beneficial health supplements like phytonutrients, hytocannabinoids, terpenes, and flavonoids.

So you might be wondering, then, why do some manufacturers use a “carrier”  oil if the hemp plant itself produces a good oil?

Well, that’s actually a very good question for if you are going to be using a full-spectrum hemp extract, then why not just use the actual hemp seed oil itself as a carrier for the CBD?

Well, as it turns out coconut oil has some specific properties that many doctors and scientists believe aids in overall absorption and metabolism. This fractionated oil is called MCT oil.

Fractionated Coconut Oil (MCT Oil)

There’s a lot of misunderstanding about MCT oil, so we’ll try and be as clear as possible here when describing why it’s used in CBD oil.

Coconut Oil has little to no flavor, which makes it a great choice for making tinctures. Additionally, it is thinner than most oils, making it easy to dispense and measure. Coconut oil has natural anti-fungal, anti-inflammatory, and anti-bacterial properties.

“MCT” itself is actually a natural extract from raw coconut oil, and it stands for medium chain triglycerides. Coconut oil has both “medium chain” and “long chain” triglycerides as part of its natural molecular componentry, but as we just mentioned there have been numerous studies that show MCT to be superior in terms of the efficiency of digestion. As such, a lot of health supplements (medicinal CBD tinctures included) have started infusing their products in MCT oils to try and market them as having “improved absorption,” or something of a similar sort.

But here’s the catch; separating the “MCT’s” from the “LCT’S” is not an easy process. In fact, it’s a very, very , very difficult process that involves highly technical instruments and a massive degree of chemical expertise. It’s assumed, in fact, that a decent majority of products labeled “MCT oil” are simply fractionated coconut oils. This doesn’t necessarily imply a good or a “bad” thing, it just simply just means that you may not be getting exactly what you think you’re getting when you see a label marked “MCT.”

 

Palm Oil

Palm oil can also be used to make MCT oil, just like coconut oil. That is because MCT oil is a somewhat general term which refers to the type of fat molecules in an oil, not the natural source of the oil. This is an important distinction because palm oil’s manufacturing process is often connected to deforestation, animal cruelty, and climate change. For this reason, it is suggested to use MCT oil which originates from coconuts, or other sustainable and eco-friendly sources.

 

Olive Oil

Olive oil has a light fruity taste, which may be noticeable in some tinctures. Additionally, olive oil tends to be thicker, which may affect the measuring process. Monounsaturated fats are the premier fat molecules in olive oil, generally in the form of oleic acid. These larger fat molecules require more processing which may reduce the amount of CBD your body absorbs. However, oleic acid may help reduce inflammation and is packed with antioxidants.

 

Avocado Oil

Similar to olive oil, avocado oil has high concentrations of oleic acid, however, it is much thicker. Avocado oil has a nutty taste and can be added to CBD oils to increase the viscosity. Avocado oil is often chosen for topical applications due to its slow drying time and abundance of vitamins A, D, & E. One downside of Avocado oil is that it is one of the more expensive oils on this list.

 

Grape Seed Oil

Grape seed oil is thin and has a wine-like aroma. It is isn’t very greasy, so grape seed oil is often incorporated into skin and hair products. Unfortunately, grape seed oil primarily consists of polyunsaturated fats which doesn’t make it the best carrier oil for CBD.

Grape seed oil is a very inexpensive carrier oil. More than likely, if you run across a CBD oil using grape seed oil as the carrier, the company is charging market price for an inferior product.

 

You can expect the best CBD oils to be made with one of these carrier oils: Coconut oil, MCT oil (this is just a natural fractionated version of coconut oil), Olive oil, or Raw Hemp Seed oil.

If the product that you’re using has anything else in the ingredients other than these things (and possibly some natural flavoring if you’re using a flavored oil tincture), then it’s advised you shop around for something else, because it’s probably not a truly “pure” cannabis product.

The main thing is that you’re using a quality-grade product that’s been extracted using super critical CO2 methods, and contains no added chemicals, thinning agents, heavy metals, pesticides, or fertilizers.

 

 

Article Sources

Myths and Realities about CBD Oil

Uncover-The-Facts-blog

 

Mark Twain once said, “There are lies, damned lies and statistics.”

That quote could have been written about the many CBD Myths that are circulated in the press and social media. Here are the facts!

~ CBD is “pot” and will get you high! Myth! CBD oil is from the hemp plant, NOT from it’s cousin the “marijuana” plant. Why is this important? Hemp is bred to increase the quality and concentration of the Cannabidiols (CBD), terpenes, and other useful bioflavonoids instead of the psychoactive THC molecule.

~ CBD is GOOD, THC is BAD! Myth! Both are useful, but for most, even a “pure” CBD oil can have tremendous health benefits as a daily supplement. THC has many potential advantages, but I would like to stick with the more mainstream CBD products.

~ CBD is illegal! Myth! Hemp-derived CBD with less than 0.3 mg% is legal to purchase and use in all 50 states.*

~ Isolates of Cannabidiol (CBD in its purest form) are better than “Full-Spectrum” CBD products. Myth! Many of the terpenes and bioflavonoids that accompany CBD in a full-spectrum product provide an amazing, rich, and healthful plant-derived supplement that an isolate cannot deliver.

~ CBD is safe in children! Truth! Studies of children given even high dose CBD oil (with THC even) show no appreciable toxicity in several clinical studies. The relatively small serving sizes in CBD products are exceedingly safe (again, you must be certain that the manufacturer of your product has reliable and independently verified analysis of contents before trusting it with your child). Although it is a supplement, I would discuss the use of the product with a CBD literate health care provider. Be aware, though, most health care providers may not know as much as you do after reading this post. We have a long way to go in Medicine before embracing naturopathic and holistic alternatives as the rule and not the exception.

~ More CBD is better! Myth! Actually, in many ways, smaller servings can achieve many of the positive health results as high-dose oils. Each individual may have different needs and deficiencies and using a premium product may be a more affordable value than you think.

~ CBD is toxic! Myth! A review of 132 studies showed an incredible safety profile, even at high doses.***

~ I will test positive on drug tests for marijuana! Myth! “Pure” CBD products contain no measurable THC, the psychoactive component tested in drug screens. Further, the 0.3mg% products have such small amounts that they are nearly impossible to measure with modern screens. One caveat though, you must know and trust the product you are using! It’s wild in the CBD space and there are no guarantees that what is labeled on the bottle is what you are actually getting in reality.

~ CBD has been clinically proven to support the reduction of anxiety, depression, social anxiety, autism, ADHD/OCD, and mood disorders. Truth! Though more research is needed to fine tune the use of CBD in many pathologies, it is clearly of significant benefit in the studies to date. Long term data has constantly shown safety in the chronic use of these products, even in children.** ***

~ CBD can support many natural and healthy functions in the body! Truth! Inflammation, digestive health, anxiety, sleep disorders, mood stabilization, enhanced immunity, and cosmetic benefits can be supported naturally and safely by regularly supplementing with CBD products, especially the full-spectrum compounds.

~ All CBD products are the same! BIG MYTH! This is the important take away here! I think we can agree that CBD based health supplements are going to be transformational in our health and wellness quests, but caveat emptor (let the buyer beware)!

Clearly, with all the thousands of products representing the CBD movement, there are all sorts of incentives to cut corners, misrepresent the product, and even commit outright fraud! So, as I have warned before, quality and trust in your product are essential. Only do business with reputable companies, companies that can show independently validated tests insuring purity, concentration, and quality. Hemp is a plant that is extremely good at “bioaccumulation.” What this means is the plant will concentrate both the good components in soil, but also toxins and pollutants. Plants grown in many parts of the country may have been exposed to fields which previously grew crops like tobacco, GMO corn, soy, wheat, etc. These crops can leave toxic residues like nicatinamides, dioxins, chemical fertilizers, pesticides, fungicides, and herbicides in the soil just waiting for the hemp plant to concentrate in the same plant tissues in which you are deriving your CBD products.

Further, how the product is produced is critically important. Many companies try to reduce costs by cutting corners on extracting the oils from the plant. Premium and quality oils are manufactured using expensive extraction techniques that eliminate any residual solvents, heavy metals, toxins, or THC in the “pure” labeled compounds. Earl Mindell gives a useful outline of how to judge a quality CBD product in his book, Healing With Hemp CBD Oil: A Simple Guide to Using Powerful and Proven Health Benefits of CBD, Oct 17, 2017, by Earl Mindell (highly recommended).

“Always do right. This will gratify some people and astonish the rest.” ~ Mark Twain

 

* So is CBD legal? If we’re talking about hemp-derived CBD, then the answer is yes. Now, the keyword here is “hemp-derived.” Because CBD from hemp has no psychoactive effects, the purchase, sales, or possession of hemp CBD products are completely legal in all 50 States. Because hemp is sometimes confused with the marijuana plant, there is still some stigma towards hemp-derived CBD, but from a legal perspective, hemp-derived CBD is completely legal and enjoys the rights of any other legal product.

**The comprehensive review of 132 original studies by Bergamaschi et al. describes the safety profile of CBD, mentioning several properties: catalepsy is not induced and physiological parameters are not altered (heart rate, blood pressure, and body temperature). Moreover, psychological and psychomotor functions are not adversely affected. The same holds true for gastrointestinal transit, food intake, and absence of toxicity for nontransformed cells. Chronic use and high doses of up to 1500 mg per day have been repeatedly shown to be well tolerated by humans.

***This review could substantiate and expand the findings of Bergamashi et al. about CBD favorable safety profile,” Kerstin and Franjo after building on studies showing the safety profile since the original 2012 Bergamashi review.

 

 

~ Stephen O’Connor, Emergency Services at Memorial Hospital and Health Care Center, CBD-Rich Hemp Oil Educator and Entrepreneur

Article Origin: https://www.linkedin.com/pulse/myths-realities-cbd-oil-stephen-o-connor

My Testimonial of the CTFO Product: Lash and Brow Growth Serum

Lash and Brow Growth Serum

Even though my main focus is health and wellness, I do like to use beauty products as well. Of course these products have to be healthy as our skin absorbs whatever we put on them.

I saw the Lash and Brow Growth Serum, a non-CBD product, and thought I would try it. I have used different brands of lash and brow growth products in the past with little to no results. I ordered it and kept an open mind with no expectations. I did not take ‘before’ pictures because, well, honestly … I wasn’t really sure if there were going to be any noticeable results.

Wow, oh wow, was I ever surprised to see the results! My eyelashes were getting longer and my eyebrows were filling in nicely. My lashes and brows felt softer and look healthier than ever before!

 

 

Another bonus was that I discovered was that mascara went on easier too. I am greatly impressed and now have a new favorite beauty product. I feel that my list of favorite beauty products will grow as I continue to use the CBD and non-CBD Beauty Products by CTFO.

Aging, Looking and Feeling Old is a Choice… and I choose not to subscribe to those outdated and useless aspects of thinking.

If you are interested in the Lash and Brow Growth Serum,  click HERE

 

~ Rev. Tiffany White Sage Woman

CTFO: Changing the Future Outcome of Health and Wealth!

Associate Logo

 

What is the Difference Between Cannabinoids and Cannabidiol?

As you set out to learn more about cannabidiol (CBD) and its properties, it’s not uncommon to find yourself confused over many of the terms related to the compound. Often times, people have a challenging time understanding how cannabidiol differs from cannabinoids, two commonly used terms that share spelling similarities and are often used interchangeably.

To begin, it’s helpful if you understand that cannabidiol (CBD) is a type of cannabinoid. In fact, it’s one of more than 100 cannabinoids found throughout the stalks, seeds, and flowers of cannabis plants like hemp. From there, let’s dive in a bit deeper to better understand how these two terms differ.

What are Cannabinoids?

 

natural-cannabinoids

 

Cannabinoids are active chemical compounds found naturally in the seeds, stalk and flowers of cannabis plants. Phytocannabinoids, a term used to describe cannabinoids derived from plants, are able to interact with our body’s natural systems because their makeups and behaviors mimic endocannabinoids, which are cannabinoids that are synthesized on demand by our own bodies.

Our bodies are set up to interact with cannabinoids. Both phytocannabinoids and endocannabinoids join with or influence cannabinoid receptors throughout the body to alter the release of neurotransmitters and encourage balance in our systems. Cannabinoids are largely responsible for the natural effects that cannabis oils, such as CBD Hemp oil, have on the body.

Scientists have so far identified over 100 phytocannabinoids found in cannabis plants like hemp. The two most abundant cannabinoids include cannabidiol (CBD) and tetrahydrocannabinol (THC).

The cannabinoid composition of a cannabis plant is wide ranging and varies by strain. Some are higher in CBD and others contain more THC. Hemp is naturally higher in CBD and contains only trace amounts of THC. 

 

What is Cannabidiol?

Cannabidiol2

Cannabidiol, also known as CBD, is among the most abundant of all the cannabinoids. It’s found in all varieties of cannabis, but dominates the makeup of hemp plants.

Thousands of scientific studies suggest that cannabidiol may hold a wide array of potential benefits. CBD has been shown in a patent by the U.S. National Institutes of Health to possess significant and antioxidant and neuroprotective properties, suggesting that it could be beneficial for treating neurological disorders like Alzheimer’s disease or multiple sclerosis. Several studies have found CBD to be effective for reducing, and in some cases eliminating, seizure activity. *

Studies have shown that cannabidiol is a non-psychoactive cannabinoid, unlike THC. Therefore, consuming CBD won’t ever cause a high or temporarily inhibit cognitive functions. This makes CBD an appealing option for children or anyone looking to incorporate the balancing effects of cannabinoids without having to experience the fuzziness of a high.

CBD Hemp Oil is made from hemp that is naturally high in CBD and low in THC. Because hemp contains only trace amounts of the cannabinoid THC, hemp oil products are non-psychoactive.

Now that you know the difference between Cannabinoids and Cannabidiol … Check out these CBD Hemp Oils and Products

Associate Logo

 

 

 

 

 

Original Article: https://echoconnection.org/difference-cannabinoids-cannabidiol

 

Can CBD Hemp Oil Help You?
Due to federal regulations, no claims can be made about any specific ailments that may be alleviated or cured with the use of CBD Hemp Oil. However, you can do your own research with the product and see if it helps you.
*These statements have not been evaluated by the Food and Drug Administration. This product/products are not intended to diagnose, treat, cure or prevent any disease.

NEW CTFO CBD HEMP PRODUCTS

All of our NEW CTFO Products will be available 

Friday, 5 October 2018

 

New Products2018 10x Pure Banner

Wholesale: $99.97 for 500 

Wholesale: $159.97 for 1500 

GAME CHANGER !!!  CTFO EXCLUSIVE and it is PATENTED 

– Blows away any competition that touts water soluble, nano technology, etc.
– Dr. Francis Reynolds explained at the Gala how historic this discovery is and the room went CRAZY. She has extensive experience in the field of molecular biology both at University of San Francisco and Yale. She has published more articles in her field than we can list and is now working with CTFO partner, 10x Pure that allows greater levels of bio-availability of our oils.

This supercharged Full Spectrum CBD Oil is Hydrophilic, meaning it can be mixed with water. It provides accelerated, increased absorption and potency and acts as an anti-bacterial and probiotic. CBD has been known to support healthy blood sugar levels, promote healthy energy levels, relieve anxiety, aid in digestion, support optimal immune function and the regeneration of healthy cells, and promote a sense of serenity and overall well-being. Perfect for anyone wanting to treat severe health challenges and regain optimal health. Each bottle contains 50 servings of Pure CBD Hemp Oil and 10xPure which can be used twice daily.

·      HYDROPHILIC: mixes with water

·      ACCELERATED, increased absorption and potency

 

 

New Products2018 CBD Gummies

Wholesale: $59.97

Gummies aren’t just for kids anymore! These gummies allow you to enjoy the benefits of pure CBD Hemp Oil in a delicious and convenient way. Each gummy contains 20 mg of CBD Hemp Oil, helping to reduce ailments and promote overall health. 30 gummies per bottle.

·      HEALTHY, delicious and effective.

·      PAIN RELIEF: Known to reduce nausea and vomiting; suppress muscle spasms; reduce seizures and convulsions.

·      WELL-BEING: Helps to relieve anxiety, reduce cravings, aid in digestion, supports optimal immune function and the regeneration of healthy cells.

 

 

New Products2018 CBD Vape Banner

Wholesale: $59.97 for the 500  & $99.97 for the 1500  

These vape oils can be used with any vape pen or device that allows a refillable cartridge. They are nicotine and THC free and have 500 mg of Pure CBD Hemp Oil per container.

·      DELICIOUS flavors

·      CONTAINS no nicotine or THC

·      COMPATIBLE with any refillable device

       Available in 2 Flavors: Blueberry Cheesecake or Natural Citrus. We will be ADDING a TON of new flavors soon. 

 

 

New Products2018 Hair Growth and Anagain

What is AnaGain? Watch this VIDEO

Wholesale: $49.97

Step 1: Hair Growth Shampoo with AnaGain

This shampoo is the first step of a 4-step system to increase hair growth. AnaGain stimulates specific signal molecules in the hair to reactivate and promote hair growth. AnaGain combined with 50 mg of CBD per container helps to give your hair the nourishment and stimulation needed to grow fuller and thicker! This product is intended to be used in a 4-step system but can be used separately.

·      STIMULATES hair growth for MEN & WOMEN

·      PROMOTES healthy hair

·      NATURAL contributor to fuller and thicker hair

 

Step 2: Hair Growth Conditioner with AnaGain

Wholesale: $49.97

This conditioner is the second step of a 4-step system to increase hair growth. AnaGain stimulates specific signal molecules in the hair to reactivate and promote hair growth. AnaGain combined with 50 mg of CBD per container helps to give your hair the nourishment and stimulation needed to grow fuller and thicker! This product is intended to be used in a 4-step system but can be used separately.

·      STIMULATES hair growth

·      PROMOTES healthy hair

·      NATURAL contributor to fuller and thicker hair

 

Step 3: Hair Growth Leave-In Solution with AnaGain

Wholesale: $49.97

This leave-in solution is the third step of a 4-step system to increase hair growth. AnaGain stimulates specific signal molecules in the hair to reactivate and promote hair growth. AnaGain combined with 100 mg of CBD per container helps to give your hair the nourishment and stimulation needed to grow fuller and thicker! This product is intended to be used in a 4-step system but can be used separately.

·      STIMULATES hair growth

·      PROMOTES healthy hair

·      NATURAL contributor to fuller and thicker hair

 

Step 4: Hair Growth Moisture Treatment with AnaGain

Wholesale: $59.97

This hair mask moisture treatment should be used once or twice weekly but can be used up to five times. This is the final step of the 4-step system to increase hair growth. AnaGain stimulates specific signal molecules in the hair to reactivate and promote hair growth. AnaGain combined with 100 mg of CBD per container helps to give your hair the nourishment and stimulation needed to grow fuller and thicker! After using the moisture treatment, follow with shampoo and conditioner. This product is intended to be used in a 4-step system but can be used separately.

·      STIMULATES hair growth

·      PROMOTES healthy hair

·      NATURAL contributor to fuller and thicker hair

 

 

New Products2018 Beauty Care Banner

Massage Oil with Anointing Oil

Wholesale: $34.97

Made with a combination of CBD Oil, Europaea (Olive) Fruit Oil, Zeylanicum (Cinnamon) Leaf Oil and more, this massage oil was created to provide a calming and soothing massage experience. This massage oil can be used on desired areas to soothe aches and pains, as well as provide comfort and relaxation!

·      SOOTHING & calming

·      PROMOTES relaxation

·      AIDS in relief of aches and pains

 

CBD Dead Sea Mud Mask with Vulcanus Kaolin – 50 mg CBD

Wholesale: $49.97

This face mask helps to cleanse and exfoliate debris and skin cells on the surface of the skin. The Vulcanus Kaolin is a clay mineral which helps to absorb excess oils, leaving your skin feeling clean and rejuvenated. This product also includes 50 mg of CBD per container.

·      CLEANSES skin

·      EXFOLIATES skin

·      REJUVENATES skin

 

CBD Your Majesty Queen of all Creams Moisturizing Cream – 20 mg CBD

Wholesale: $39.97

Treat your skin the way it deserves to be treated! This moisturizing cream is packed full of the best ingredients, including 20 mg of CBD Oil per container, to help your skin feel refreshed, youthful and moisturized. This cream can be used daily to maintain moisture on normal skin, to provide moisture for dry skin or to balance moisture for oily skin. It is great for sensitive skin, dry and cracked skin, provides skin relief for cold weather and provides a protective layer over your skin to protect against the environment. This product can be used on the face or the body twice daily.

·      MOISTURIZES skin

·      COMBATS the aging process

·      Leaves skin feeling REFRESHED

 

500 mg CBD Ultimate Deep Healing Pain Cream with Emu Oil

Wholesale: $79.97

Our Ultimate Deep Healing Pain Cream with Emu Oil contains 500 mg of CBD oil and helps to deeply penetrate the toughest aches & sores. Natural anti-inflammatory properties from Emu Oil combined with our hemp intensive formula. Apply as needed to problem areas. Great for chronic conditions! Apply to areas experiencing tension or pain. This product can be used as often as necessary.

·      RELIEVES pain

·      HYDRATES skin

AIDS joint ailments and stiffness

 

 

NON – CBD PRODUCTS:

 

Non-CBD Dead Sea Mud Mask with Vulcanus Kaolin

Wholesale: $39.97

This face mask helps to cleanse and exfoliate debris and skin cells on the surface of the skin. The Vulcanus Kaolin is a clay mineral which helps to absorb excess oils, leaving your skin feeling clean and rejuvenated.

·      CLEANSES skin

·      EXFOLIATES skin

·      REJUVENATES skin

 

Non-CBD 2.5% Retinol Complex Serum

Wholesale: $36.97

Want radiant skin? This serum was made for you! This product is strong yet gentle and helps fight signs of aging while keeping your skin soft and glowing. Retinol stimulates the production of new skin cells while helping to fade dark spots and even out other skin discoloration. It helps renew the skin and treat acne while also reducing the appearance of fine lines and wrinkles.

·      REDUCES the appearance of fine lines & wrinkles

·      PROMOTES healthy, radiant skin

·      ANTI-AGING formula combats the aging process

 

Non-CBD Your Majesty Queen of all Creams Moisturizing Cream

Wholesale: $34.97

Treat your skin the way it deserves to be treated! This moisturizing cream is packed full of the best ingredients to help your skin feel refreshed, youthful and moisturized. This cream can be used daily to maintain moisture on normal skin, to provide moisture for dry skin or to balance moisture for oily skin. It is great for sensitive skin, dry and cracked skin, provides skin relief for cold weather and provides a protective layer over your skin to protect against the environment. This product can be used on the face or the body twice daily.

·      MOISTURIZES skin

·      COMBATS the aging process

·      Leaves skin feeling REFRESHED

 

On October 5th, they will be available for Ordering. 

Order HERE

 

Associate Logo

 

 

Drugs that may Interact with CBD Hemp Oil

CBD and Drug Interactions

 

If you are on one or several medications, you may want to print this out or save the link, to share this information with your doctor for both of you to discuss the best course of action for your health and wellness plan. 

Research has begun to demonstrate that cannabidiol (CBD) has the potential to effectively help a large number of people. CBD interacts with the endocannabinoid system in a way that produces very few unintended side-effects.

While the majority of the vast majority of the science indicates CBD is safe for use and consumption, it does pose a few risks that, if not properly understood, could be dangerous. One of these risks is the inhibition of the cytochrome P450 enzyme system.

What is the Cytochrome P-450 System?

Found within the liver, the cytochrome P450 enzyme system is responsible for metabolizing potentially toxic compounds, including over 60% percent of any drugs you have consumed.

According to Davis’s Drug Guide, this system contains more than 50 enzymes that process and eliminate toxins.

Why Does CYP450 Matter?

In order to determine the appropriate dosages of medications, doctors make calculations using the average amount of time it takes for various drugs and medications to be processed through the cytochrome P450 system.

If only one drug is being processed, and the system is generally healthy, these averages provide accurate dosage information.

However, certain substances have the ability to affect processing times within this system, making drugs metabolize faster or slower than they would on their own.

Similarly, if the cytochrome P450 system is unhealthy due to problems with the liver or other pre-existing conditions, drugs may not metabolize as they should.

Cannabidiol in the Cytochrome P-450 System

Cannabidiol can inhibit the cytochrome P450 system’s ability to metabolize certain drugs, leading to an overall increase in processing times.

Interestingly, CBD is not alone in its effect on drug metabolism. Grapefruit, watercress, St. John’s Wort, and goldenseal all have a similar impact in terms of CYP450 inhibition.

When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.

If you are taking a medication affected by cannabidiol, you should consult your doctor to make sure that it is safe for you to supplement your personal care routine with CBD Hemp. From there, the two of you may consider adjusting the dosage on your medications so that you can use both products safely.  

 

Drugs that Interact with Cannabidiol

Any drug metabolized by CYP450 enzymes could potentially interact with cannabidiol. According to the Indiana University Department of Medicine, drugs known to use the CYP450 system include:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDs
  • Angiotension II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

 

This list does not include all of the potential medications impacted by cannabidiol. Nor will every medication in the categories contained on this list will cause an interaction. For these reasons, you should consult with a medical professional before supplementing with CBD Hemp products.

There are certain medications, known as “prodrugs,” that need to be metabolized to produce the therapeutic compound. In other words, you ingest an inactive compound and once in the body, it is processed into the active drug. If this processing is dependent on CYP3A4 (part of the larger CYP450 system), then inhibitors can result in too little active drug in the body for the desired therapeutic effect.

Codeine, for example, is a prodrug that is metabolized into morphine which provides the effect.

Vyvanse and Concerta are two other popular pharmaceutical medications for ADHD that fall into this category.

If you are worried that your CYP450 pathway may not be functioning properly, physicians can test the system to ensure that the medications you take are metabolizing as expected.

If you are on one or several medications, you may want to print this out or save the link, to share this information with your doctor for both of you to discuss the best course of action for your health and wellness plan. 

 

Combining Alcohol and CBD Oil

Alcohol and cannabis are both widely consumed in our society and the effects of combining the two are well known.

What is less understood by the general public, is the effects of combining alcohol and the cannabinoid compound CBD.

Alcohol depends on a few different metabolic pathways in the human body, with the primary enzymes involved being:

  • Alcohol dehydrogenase (ADH)
  • Aldehyde dehydrogenase (ALDH)
  • CYP450 (specifically CYP2E1)

In people who only drink socially or occasionally, ADH and ALDH handle the entire workload of metabolizing ethanol. However, when binge drinking (or during chronic consumption of alcohol) CYP450 gets involved to assist the overloaded ADH and ALDH pathways.

Here are some interesting tidbits about alcohol and CBD:

  • The CB1 receptor is a significant player in the reinforcing and motivating attributes of alcohol. [S]
  • Combining alcohol and CBD results in significantly lower blood levels of alcohol. [S]
  • CBD reduces the reinforcement, motivation and relapse for alcohol. [S]
  • CBD protects the liver from damage done by binge-drinking alcohol. [S]
  • CBD prevents against alcohol-induced neurodegeneration. [S]
  • CBD attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury. [S]
  • Cannabinoids have an effect on nearly all enzymes responsible for metabolizing alcohol. [S]
  • CB1 receptor agonists (THC) encourage alcohol consumption, while CB1 receptor antagonists (CBD) decrease it. [S]

Although the pharmacokinetics of alcohol and CBD are not yet well-understood, what we do know is CBD inhibits the CYP450 enzyme system, and this system plays a significant role in alcohol metabolism. Additionally, as found in mice, CBD alters levels of ADH and ALDH to varying degrees.

It is important to be mindful and cautious when mixing CBD and alcohol.

 

 

Original Article:  https://cbdoilreview.org/cbd-cannabidiol/cbd-p-450-enzyme

 

CBD helps with Sleep and Insomnia.

Complications_of_insomnia

Insomnia In The U.S. is still a pressing Public Health Problem.

According to a recent Huffington Post article by Catherine Pearson, “Sleep is a major problem for many Americans, according to a new report that acts as a kind of “state-of-insomnia” in the U.S. The review, published online by the medical journal The Lancet, finds that nearly a quarter of adults are unhappy with their sleep patterns, while up to 10 percent meet the criteria for full-fledged insomnia, putting them at a greater risk for depression, hypertension and diabetes.”

It’s easy to joke about this issue… but it’s no joke. Why do so many of us have trouble falling asleep or sleeping through the night? Some say it’s our stress-filled lifestyles. Some say it’s a by-product of anxiety. Some say we’ve become dependent on alcohol or over-the-counter drugs to help us sleep. The truth is, using these crutches may actually interfere with the deep “REM” sleep that we all need for rest and recuperation.

 

Sleep Support Oral Spray Banner

 

 

CTFO’s Sleep Support Oral Spray uses a combination of CBD and Melatonin to help you fall asleep naturally and without drugs or alcohol. Both of these natural ingredients have been shown to relax you and help you fall asleep. Some of our customers even say the CBD drops alone help them fall asleep.

With better quality sleep, we can all have more peaceful nights and better overall health.

Purchase CTFO’s Sleep Support Oral Spray HERE

 

 

Catherine Pearson’s article: https://www.huffingtonpost.com/2012/01/20/insomnia-health-problem-study_n_1217093.html